Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Gerald Ehrenstein; Li Yen Mae Huang

doi:10.1126/science.7313696

Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Gerald Ehrenstein, Li Yen Mae Huang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.

Original language	English (US)
Pages (from-to)	1365-1366
Number of pages	2
Journal	Science
Volume	214
Issue number	4527
DOIs	https://doi.org/10.1126/science.7313696
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.7313696

Cite this

@article{d69a2b7b599a4eeca3b41df376b8a8ad,

title = "Side-effect reduction by use of drugs that bind to separate but equivalent binding sites",

abstract = "If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.",

author = "Gerald Ehrenstein and Huang, {Li Yen Mae}",

year = "1981",

doi = "10.1126/science.7313696",

language = "English (US)",

volume = "214",

pages = "1365--1366",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4527",

}

TY - JOUR

T1 - Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

AU - Ehrenstein, Gerald

AU - Huang, Li Yen Mae

PY - 1981

Y1 - 1981

N2 - If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.

AB - If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.

UR - http://www.scopus.com/inward/record.url?scp=0019799798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019799798&partnerID=8YFLogxK

U2 - 10.1126/science.7313696

DO - 10.1126/science.7313696

M3 - Article

C2 - 7313696

AN - SCOPUS:0019799798

SN - 0036-8075

VL - 214

SP - 1365

EP - 1366

JO - Science

JF - Science

IS - 4527

ER -

Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this