Should prostate cancer be considered as a differential diagnosis in patients with osteolytic bone lesions?

M. U. Bakhsh, S. Lee, S. Ahmad, J. Takher, A. Pareek, U. Syed, J. Seashore, E. Szemraj

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


OBJECTIVE: Prostate cancer is the most frequently diagnosed cancer in men, as well as the second leading cause of death among cancers after lung cancer. In the United States, it is more prevalent in African-American men than in Caucasian men. Prostate cancer frequently metastasizes to the bone, with most of the reported lesions appearing to be osteoblastic on radiographs. Here, we describe an unusual presentation of metastatic prostate cancer with diffuse osteolytic bone lesions. CASE PRESENTATION: An 80-year-old previously healthy Hispanic man presented with worsening back pain, difficulty with ambulation, and bladder outlet obstruction. Physical examination was significant for spinal tenderness in the thoracic and lumbar region. Digital rectal examination was remarkable for asymmetric enlargement of the prostate with nodularity and firmness. Imaging studies revealed diffuse osteolytic lesions. His prostate-specific antigen was 562.8 ng/mL (normal 0-4). Prostate biopsy and imaging studies confirmed a diagnosis of metastatic prostate cancer. CONCLUSIONS: This case demonstrates that bone metastases of prostate cancer are not purely osteoblastic although most of the reported bone metastases in prostate cancer have been osteoblastic in nature. Therefore, clinicians are to consider metastatic prostate cancer as a differential diagnosis for patients with osteolytic bone lesions.

Original languageEnglish (US)
Pages (from-to)4791-4794
Number of pages4
JournalEuropean Review for Medical and Pharmacological Sciences
Issue number24
StatePublished - 2015
Externally publishedYes


  • Bone metastases
  • Metastatic prostate cancer
  • Osteoblastic
  • Osteolytic

ASJC Scopus subject areas

  • Pharmacology (medical)


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