Shedding UV Light on Alternative Splicing

Matthew S. Marengo, Mariano A. Garcia-Blanco

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
Issue number4
StatePublished - May 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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