TY - JOUR
T1 - Severe menorrhagia, unilateral ovarian mass, elevated inhibin levels, and severe hypothyroidism
T2 - An unusual presentation of Van Wyk and Grumbach syndrome
AU - Tran, Sifrance
AU - Kim, Ellen E.
AU - Chin, Anthony C.
PY - 2013/1
Y1 - 2013/1
N2 - Abstract A 10 year old female presented with a 3 week history of persistent vaginal bleeding, lower abdominal pain, and generalized fatigue. Further work-up determined that she had severe autoimmune hypothyroidism, precocious puberty, and a large left cystic ovarian mass, consistent with Van Wyk and Grumbach syndrome. In addition, the patient had elevated inhibin A and B levels, which may be elevated in granulosa cell tumor. The patient was managed with thyroid hormone replacement therapy and careful observation. Complete resolution of the ovarian mass and interval normalization of the inhibin levels were achieved. In females with severe primary hypothyroidism, ovarian masses, and elevated tumor markers, operative resection may be avoided with appropriate thyroid replacement therapy and close observation.
AB - Abstract A 10 year old female presented with a 3 week history of persistent vaginal bleeding, lower abdominal pain, and generalized fatigue. Further work-up determined that she had severe autoimmune hypothyroidism, precocious puberty, and a large left cystic ovarian mass, consistent with Van Wyk and Grumbach syndrome. In addition, the patient had elevated inhibin A and B levels, which may be elevated in granulosa cell tumor. The patient was managed with thyroid hormone replacement therapy and careful observation. Complete resolution of the ovarian mass and interval normalization of the inhibin levels were achieved. In females with severe primary hypothyroidism, ovarian masses, and elevated tumor markers, operative resection may be avoided with appropriate thyroid replacement therapy and close observation.
KW - Hypothyroidism
KW - Inhibin A
KW - Inhibin B
KW - Ovarian mass
KW - Tumor markers
KW - Van Wyk-Grumbach syndrome
UR - http://www.scopus.com/inward/record.url?scp=84872404149&partnerID=8YFLogxK
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U2 - 10.1016/j.jpedsurg.2012.10.064
DO - 10.1016/j.jpedsurg.2012.10.064
M3 - Article
C2 - 23331842
AN - SCOPUS:84872404149
SN - 0022-3468
VL - 48
SP - E51-E54
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 1
ER -