Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California

Michele Jay; Michael S. Ascher; Bruno B. Chomel; Minoo Madon; David Sesline; Barryett A. Enge; Brian Hjelle; Thomas G. Ksiazek; Pierre E. Rollin; Philip H. Kass; Kevin Reilly

doi:10.3201/eid0302.970213

Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California

Michele Jay, Michael S. Ascher, Bruno B. Chomel, Minoo Madon, David Sesline, Barryett A. Enge, Brian Hjelle, Thomas G. Ksiazek, Pierre E. Rollin, Philip H. Kass, Kevin Reilly

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (>1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.

Original language	English (US)
Pages (from-to)	183-190
Number of pages	8
Journal	Emerging infectious diseases
Volume	3
Issue number	2
DOIs	https://doi.org/10.3201/eid0302.970213
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California",

abstract = "A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (>1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.",

author = "Michele Jay and Ascher, {Michael S.} and Chomel, {Bruno B.} and Minoo Madon and David Sesline and Enge, {Barryett A.} and Brian Hjelle and Ksiazek, {Thomas G.} and Rollin, {Pierre E.} and Kass, {Philip H.} and Kevin Reilly",

year = "1997",

doi = "10.3201/eid0302.970213",

language = "English (US)",

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pages = "183--190",

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AU - Jay, Michele

AU - Ascher, Michael S.

AU - Chomel, Bruno B.

AU - Madon, Minoo

AU - Sesline, David

AU - Enge, Barryett A.

AU - Hjelle, Brian

AU - Ksiazek, Thomas G.

AU - Rollin, Pierre E.

AU - Kass, Philip H.

AU - Reilly, Kevin

PY - 1997

Y1 - 1997

N2 - A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (>1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.

AB - A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (>1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.

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Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California

Abstract

ASJC Scopus subject areas

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