TY - JOUR
T1 - Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography
AU - Adhi, Mehreen
AU - Jusufbegovic, Denis
AU - Schaal, Shlomit
N1 - Publisher Copyright:
© Taylor & Francis Group, LLC.
PY - 2017/7/4
Y1 - 2017/7/4
N2 - Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.
AB - Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.
KW - Choroidal neovascular membrane
KW - histo spots
KW - pigment epithelial detachment
KW - presumed ocular histoplasmosis syndrome
KW - spectral-domain optical coherence tomography
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U2 - 10.3109/09273948.2016.1158841
DO - 10.3109/09273948.2016.1158841
M3 - Article
C2 - 27082105
AN - SCOPUS:84963847222
SN - 0927-3948
VL - 25
SP - 545
EP - 553
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 4
ER -