Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis

Joke Beuten, Dawn Garcia, Timothy C. Brand, Xin He, Ivana Balic, Edith Canby-Hagino, Dean A. Troyer, Jacques Baillargeon, Javier Hernandez, Ian M. Thompson, Robin J. Leach, Susan L. Naylor

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: SEMA3B and SEMA3F are 2 closely related genes lying 80 kb apart on chromosome 3 that have been shown to suppress tumor formation in vivo and in vitro. Each gene has a single nucleotide polymorphism that results in a nonsynonymous coding change, rs2071203 (SEMA3B) and rs1046956 (SEMA3F), as well as noncoding single nucleotide polymorphisms. Materials and Methods: We performed a case-control study of 789 prostate cancer cases and 907 controls from 3 races/ethnicities to determine possible associations of 10 variants with prostate cancer risk or prognosis. Results: The risk of prostate cancer increased more than 2-fold in Hispanic men with TT alleles at rs2071203 in SEMA3B and with CC alleles for rs2072054 at the 5′ end of SEMA3F (OR 2.13, 95% CI 1.12-4.04, p = 0.02 and OR 2.55, 95% CI 1.34-4.84, p = 0.0045, respectively). These 2 single nucleotide polymorphisms were also associated with a poor prognosis in Hispanic men (2.71 and 3.48-fold increased risk). A frequent G-C-G-G-A-T-C-C-T-G haplotype encompassing 10 SNPs was associated with an increased risk of prostate cancer and poor prognosis in Hispanic samples (OR 2.72, 95% CI 1.20-6.12, p = 0.016 and OR 3.32, 95% CI 1.21-9.10, p = 0.02). In nonHispanic white men the T-C-G-A-A-T-C-C haplotype was associated with a high Gleason score (OR 1.44, 95% CI 1.06-1.96, p = 0.021). Conclusions: These data indicate that polymorphisms in SEMA3B and SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men.

Original languageEnglish (US)
Pages (from-to)1614-1620
Number of pages7
JournalJournal of Urology
Issue number4 SUPPL.
StatePublished - Oct 2009
Externally publishedYes


  • continental population groups
  • polymorphism
  • prostate
  • prostatic neoplasms
  • semaphorins
  • single nucleotide

ASJC Scopus subject areas

  • Urology


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