Selective photocoagulation of cutaneous blood vessels: Evaluation of vessel damage by color Doppler optical coherence tomography

Gracie Vargas, Mathieu Ducros, Susan Dozier, Jennifer Kehlet Barton, Ashley J. Welch

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


This study investigates the threshold radiant exposures required to irreversibly damage cutaneous blood vessels using a pulsed dye laser (PDL) operating at 585 nm. Evaluation of blood vessel damage and blood flow stoppage was achieved using Doppler imaging in a color Doppler optical coherence tomographic (CDOCT) system. Hamster dorsal skin flap window vessels were irradiated with radiant exposures ranging from 2.5-8 J/cm2. A 5 mm spot size and 360 μs pulse duration were used. Irradiation sites were imaged with CDOCT prior to, immediately after, and a minimum of 24 hours after delivery of laser energy. Magnitude and color Doppler images provided information such as approximate vessel size, depth, and changes in blood flow velocity. Vessel stenosis, temporary occlusion, permanent occlusion, hemorrhaging, and changes in flow velocity were frequent results of laser irradiation visualized with CDOCT and video imaging. Probit analysis was used to estimate the 50% probability that a blood vessel of given size and type will be destroyed by a given radiant exposure. In most instances, arterioles required higher radiant exposures to be irreversibly damaged than venules of the same size. However, arteriole/venule pairs required approximately the same radiant exposures for visible damage to occur. Vessels of larger diameter required higher radiant exposures to coagulate than vessels of smaller diameter.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2000
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems X - San Jose, CA, USA
Duration: Jan 22 2000Jan 25 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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