TY - JOUR
T1 - Screening for major depression in persons with HIV infection
T2 - The concurrent predictive validity of the Profile of Mood States Depression-Dejection Scale
AU - Patterson, Katherine
AU - Young, Corinna
AU - Woods, Steven Paul
AU - Vigil, Ofilio
AU - Grant, Igor
AU - Atkinson, J. Hampton
AU - McCutchan, J. Allen
AU - Marcotte, Thomas D.
AU - Wallace, Mark R.
AU - Ellis, Ronald J.
AU - Letendre, Scott
AU - Schrier, Rachel
AU - Heaton, Robert K.
AU - Cherner, Mariana
AU - Dawes, Sharron
AU - Lu, Lei
AU - Jernigan, Terry
AU - Hesselink, John
AU - Taylor, Michael J.
AU - Masliah, Eliezer
AU - Langford, Dianne
AU - Frybarger, Michelle
AU - Abramson, Ian
AU - Lazzaretto, Deborah
PY - 2006
Y1 - 2006
N2 - Major Depressive Disorder (MDD) is among the most prevalent but underdiagnosed psychiatric disorders in persons with HIV infection. Given the known adverse impact of comorbid MDD on HIV disease progression and health-related quality of life, it is important both for research and for efficient, effective clinical care, to validate existing screening measures that may discriminate between MDD and the somatic symptoms of HIV (such as fatigue). In the current study, we evaluated the concurrent predictive validity of the Profile of Mood States (POMS) Depression-Dejection scale in detecting current MDD in 310 persons with HIV infection. The Structured Clinical Interview for DSM-IV (SCID) diagnosis of MDD and the Cognitive-Affective scale from the Beck Depression Inventory (BDI-CA) served as comparative diagnostic and severity measures of depression, respectively. Results demonstrated that the POMS Depression-Dejection scale accurately classified persons with and without MDD SCID diagnoses, with an overall hit rate of 80%, sensitivity of 55%, specificity of 84%, and negative predictive power of 91% using a recommended cutpoint of 1.5 standard deviations above the normative mean. Moreover, the POMS performed comparably to the BDI-CA in classifying MDD. Findings support the predictive validity of the POMS Depression-Dejection scale as a screening instrument for MDD in persons with HIV disease.
AB - Major Depressive Disorder (MDD) is among the most prevalent but underdiagnosed psychiatric disorders in persons with HIV infection. Given the known adverse impact of comorbid MDD on HIV disease progression and health-related quality of life, it is important both for research and for efficient, effective clinical care, to validate existing screening measures that may discriminate between MDD and the somatic symptoms of HIV (such as fatigue). In the current study, we evaluated the concurrent predictive validity of the Profile of Mood States (POMS) Depression-Dejection scale in detecting current MDD in 310 persons with HIV infection. The Structured Clinical Interview for DSM-IV (SCID) diagnosis of MDD and the Cognitive-Affective scale from the Beck Depression Inventory (BDI-CA) served as comparative diagnostic and severity measures of depression, respectively. Results demonstrated that the POMS Depression-Dejection scale accurately classified persons with and without MDD SCID diagnoses, with an overall hit rate of 80%, sensitivity of 55%, specificity of 84%, and negative predictive power of 91% using a recommended cutpoint of 1.5 standard deviations above the normative mean. Moreover, the POMS performed comparably to the BDI-CA in classifying MDD. Findings support the predictive validity of the POMS Depression-Dejection scale as a screening instrument for MDD in persons with HIV disease.
KW - Human immunodeficiency virus
KW - Major depression
KW - Psychological assessment
KW - Screening tests
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U2 - 10.1002/mpr.184
DO - 10.1002/mpr.184
M3 - Article
C2 - 19722288
AN - SCOPUS:34447250785
SN - 1049-8931
VL - 15
SP - 75
EP - 82
JO - International Journal of Methods in Psychiatric Research
JF - International Journal of Methods in Psychiatric Research
IS - 2
ER -