TY - JOUR
T1 - Scientific vs. statistical inference
T2 - the problem of multiple contrasts in clinical research.
AU - Ottenbacher, K. J.
PY - 1988/3
Y1 - 1988/3
N2 - The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.
AB - The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.
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U2 - 10.1097/00000441-198803000-00002
DO - 10.1097/00000441-198803000-00002
M3 - Article
C2 - 3354590
AN - SCOPUS:0023968265
SN - 0002-9629
VL - 295
SP - 172
EP - 177
JO - The American journal of the medical sciences
JF - The American journal of the medical sciences
IS - 3
ER -