Safety of recombinant VSV-Ebola virus vaccine vector in pigs

Emmie De Wit; Andrea Marzi; Trenton Bushmaker; Doug Brining; Dana Scott; Juergen A. Richt; Thomas W. Geisbert; Heinz Feldmann

doi:10.3201/eid2104.142012

Safety of recombinant VSV-Ebola virus vaccine vector in pigs

Emmie De Wit, Andrea Marzi, Trenton Bushmaker, Doug Brining, Dana Scott, Juergen A. Richt, Thomas W. Geisbert, Heinz Feldmann

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.

Original language	English (US)
Pages (from-to)	702-704
Number of pages	3
Journal	Emerging infectious diseases
Volume	21
Issue number	4
DOIs	https://doi.org/10.3201/eid2104.142012
State	Published - 2015

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid2104.142012

Cite this

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abstract = "The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.",

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AU - De Wit, Emmie

AU - Marzi, Andrea

AU - Bushmaker, Trenton

AU - Brining, Doug

AU - Scott, Dana

AU - Richt, Juergen A.

AU - Geisbert, Thomas W.

AU - Feldmann, Heinz

PY - 2015

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AB - The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.

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Safety of recombinant VSV-Ebola virus vaccine vector in pigs

Abstract

ASJC Scopus subject areas

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