ROS Signalling of inflammatory cytokines during trypanosoma cruzi infection

Shivali Gupta, Monisha Dhiman, Jian jun Wen, Nisha Jain Garg

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Scopus citations


Inflammation is a host defence activated by exogenous (e.g. pathogen-derived, pollutants) or endogenous (e.g. reactive oxygen species-ROS) danger signals. Mostly, endogenous molecules (or their derivatives) have well-defined intracellular function but become danger signal when released or exposed following stress or injury. In this review, we discuss the potential role of ROS in chronic evolution of inflammatory cardiovascular diseases, using our experiences working on chagasic cardiomyopathy as a focus-point.

Original languageEnglish (US)
Title of host publicationAdvances in Parasitology
PublisherAcademic Press
Number of pages18
StatePublished - 2011

Publication series

NameAdvances in Parasitology
ISSN (Print)0065-308X


  • Chagas
  • Cytokines
  • Inflammation
  • Oxidative stress
  • ROS
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Parasitology


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