Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5)

Aline Aparecida Silva Barbosa, Alice Freitas Versiani, Larissa Fonseca da Cunha Sousa, Aline Silva de Miranda, Marcela Ribeiro Gasparini, Fátima Brant, Daniele Gonçalves Silva, Iracema Luisa Quintino-de-Carvalho, Frederico Marianetti Soriani, Flávio Guimarães da Fonseca, Anilton César Vasconcelos, Lucíola da Silva Barcelos, Mauro Martins Teixeira, Antônio Lúcio Teixeira, Fabiana Simão Machado, Edel Figueiredo Barbosa-Stancioli, Milene Alvarenga Rachid

Research output: Contribution to journalArticlepeer-review


The role of suppressors of cytokine signaling (SOCS) in meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5) was evaluated by intracranial infection in C57BL/6 wild-type mice (WT) and SOCS2 deficient mice (SOCS2-/-). Both infected groups presented weight loss, ruffled fur and hunched posture. Additionally, infected SOCS2-/- mice showed swollen chamfer and progressive depression. Infected WT animals developed mild meningitis, characterized by infiltration of mononuclear cells. Moreover, viral DNA was detected in liver and lung from infected WT group. This group also showed elevated brain levels of IFN-γ, IL-10, CXCL1 and CCL5, when compared with non-infected WT animals. Brain inflammation was exacerbated in infected SOCS2-/- mice with widespread distribution of the virus and increased brain levels of TNF-α, IFN-γ, IL-10, IL-12, CXCL1 and CCL5, when compared with WT infected mice. Moreover, infected SOCS2 deficient mice exhibited reduced brain mRNA expression of IFNα and IFNβ and increased expression of mRNA of SOCS1, compared with infected WT mice. Taken together, our study provides an insight into the role of SOCS2 in modulating the immune response to BoHV-5 infection.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalComparative Immunology, Microbiology and Infectious Diseases
StatePublished - Aug 1 2016
Externally publishedYes


  • Bovine herpesvirus 5
  • Brain
  • Inflammation
  • Mice
  • SOCS2

ASJC Scopus subject areas

  • Infectious Diseases
  • General Veterinary
  • Immunology and Allergy
  • Microbiology
  • Immunology


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