Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis

Steven I. Wolinsky; James S. Goodwin; Ronald P. Messner; Ralph C. Williams

doi:10.1016/0090-1229(80)90070-7

Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis

Steven I. Wolinsky, James S. Goodwin, Ronald P. Messner, Ralph C. Williams

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Peripheral blood mononuclear cells from patients with rheumatoid arthritis have a depressed response to phytohemagglutinin in vitro. This depression was partly reversed by adding indomethacin, a prostaglandin synthetase inhibitor, to the cultures. Removal of glass-adherent cells prior to culture did not affect the depressed mitogen response of the patients' cells. The phytohemagglutinin response of peripheral blood mononuclear cells from rheumatoid arthritis patients was more sensitive than normal to inhibition by exogenous prostaglandin E₂.

Original language	English (US)
Pages (from-to)	31-37
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(80)90070-7
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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AU - Goodwin, James S.

AU - Messner, Ronald P.

AU - Williams, Ralph C.

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Y1 - 1980

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AB - Peripheral blood mononuclear cells from patients with rheumatoid arthritis have a depressed response to phytohemagglutinin in vitro. This depression was partly reversed by adding indomethacin, a prostaglandin synthetase inhibitor, to the cultures. Removal of glass-adherent cells prior to culture did not affect the depressed mitogen response of the patients' cells. The phytohemagglutinin response of peripheral blood mononuclear cells from rheumatoid arthritis patients was more sensitive than normal to inhibition by exogenous prostaglandin E2.

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Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis

Abstract

ASJC Scopus subject areas

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