Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: The therapeutic potential of PARP inhibitors

INIS

• injuries 100%
• polymerases 100%
• adp 100%
• cardiovascular diseases 100%
• ribose 100%
• enzymes 50%
• aging 50%
• ischemia 50%
• atherosclerosis 50%
• angiogenesis 50%
• hypertrophy 50%
• heart failure 50%
• oxidation 25%
• knock-out reactions 25%
• mice 25%
• oxygen 25%
• nitrogen 25%
• cancer 25%
• animals 25%
• inflammation 25%
• death 25%
• dna damages 25%
• kinases 25%
• substrates 25%
• reviews 25%
• inhibition 25%
• transport 25%
• atp 25%
• vitamin d 25%
• estrogens 25%
• electrons 25%
• nad 25%
• glycolysis 25%
• purines 25%
• antineoplastic drugs 25%
• thyroid hormones 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Cardiovascular Disease 100%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 100%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 100%
• Injury 50%
• Atherosclerosis 50%
• Enzyme 50%
• Cardiomyopathy 50%
• Shock 50%
• Heart Ventricle Hypertrophy 50%
• Heart Failure 50%
• Vascular Remodeling 50%
• Myocardial Ischemia Reperfusion Injury 50%
• Reactive Oxygen Metabolite 25%
• Reactive Nitrogen Species 25%
• DNA 25%
• Malignant Neoplasm 25%
• Knockout Mouse 25%
• Death 25%
• Anticarcinogen 25%
• Phosphotransferase 25%
• Adenosine Triphosphate 25%
• Vitamin D 25%
• Estrogen 25%
• Polyamine 25%
• Purine Derivative 25%
• Therapeutic Effect 25%
• Diabetic Complication 25%
• Thyroid Hormone 25%
• Functional Disease 25%

Keyphrases

• Therapeutic Potential 100%
• Cardiovascular Disease 100%
• PARP Inhibitor (PARPi) 100%
• Endothelial Cells 25%
• Atherosclerosis 25%
• Cardiomyocytes 25%
• Angiogenesis 25%
• Cardiomyopathy 25%
• Myocardial Hypertrophy 25%
• Heart Failure 25%
• Vascular Remodeling 25%
• Circulatory Shock 25%
• Cardiac Aging 25%
• Myocardial Ischemia-reperfusion Injury 25%
• Reactive Oxygen Species 12%
• Reactive Nitrogen Species 12%
• Cancer Treatment 12%
• Knock-in Mouse Model 12%
• Reactive Species 12%
• Thyroid Hormones 12%
• Diabetes Complications 12%
• Vitamin D 12%
• Estrogen 12%
• Inflammatory Pathways 12%
• Glycolysis 12%
• Oxidative DNA Damage 12%
• Purine 12%
• Therapeutic Effect 12%
• Anticancer Drugs 12%
• Pharmacological Inhibitors 12%
• Diabetic Vascular Complications 12%
• Functional Impairment 12%
• Clinical Development 12%
• Nicotinamide Adenine Dinucleotide (NAD+) 12%
• Electron Transport 12%
• PARP Activation 12%
• Endogenous Factors 12%
• Polyamines 12%
• Overactivation 12%
• Significant Benefit 12%
• ATP Formation 12%
• Enzyme Family 12%
• PARP Enzymes 12%