TY - JOUR
T1 - Role of Periodontal Infection, Inflammation and Immunity in Atherosclerosis
AU - Choi, Harry
AU - Dey, Amit K.
AU - Priyamvara, Aditi
AU - Aksentijevich, Milena
AU - Bandyopadhyay, Dhrubajyoti
AU - Dey, Debashish
AU - Dani, Sourbha
AU - Guha, Avirup
AU - Nambiar, Puja
AU - Nasir, Khurram
AU - Jneid, Hani
AU - Mehta, Nehal N.
AU - Lavie, Carl J.
AU - Amar, Salomon
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Background: Inflammation plays a major role in the development and progression of cardiovascular disease (CVD) morbidity and mortality. The well-established relationship between periodontal disease (PD) and CVD may be causal. Left untreated, PD can lead to high systemic inflammation, thus contributing to inflammatory CVD, such as atherosclerosis. Multiple mechanisms have been proposed to elucidate the causal relationship between PD and its contribution to CVD. Objective: This review article highlights the current evidence supporting the role of PD in the development and progression of atherosclerosis. Methods: After creating a list of relevant medical subject heading (MeSH) terms, a systematic search within PubMed in English for each MeSH term between 2000 and 2019 was used to generate evidence for this review article. Conclusion: There is overwhelming evidence in the current literature that supports an association between PD and CVD that is independent of known CVD risk factors. However, the supporting evidence that PD directly causes CVD in humans continues to remain elusive. Multiple biologically plausible mechanisms have been proposed and investigated, yet most studies are limited to mouse models and in vitro cell cultures. Additional studies testing the various proposed mechanisms in longitudinal human studies are required to provide deeper insight into the mechanistic link between these 2 related diseases.
AB - Background: Inflammation plays a major role in the development and progression of cardiovascular disease (CVD) morbidity and mortality. The well-established relationship between periodontal disease (PD) and CVD may be causal. Left untreated, PD can lead to high systemic inflammation, thus contributing to inflammatory CVD, such as atherosclerosis. Multiple mechanisms have been proposed to elucidate the causal relationship between PD and its contribution to CVD. Objective: This review article highlights the current evidence supporting the role of PD in the development and progression of atherosclerosis. Methods: After creating a list of relevant medical subject heading (MeSH) terms, a systematic search within PubMed in English for each MeSH term between 2000 and 2019 was used to generate evidence for this review article. Conclusion: There is overwhelming evidence in the current literature that supports an association between PD and CVD that is independent of known CVD risk factors. However, the supporting evidence that PD directly causes CVD in humans continues to remain elusive. Multiple biologically plausible mechanisms have been proposed and investigated, yet most studies are limited to mouse models and in vitro cell cultures. Additional studies testing the various proposed mechanisms in longitudinal human studies are required to provide deeper insight into the mechanistic link between these 2 related diseases.
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U2 - 10.1016/j.cpcardiol.2020.100638
DO - 10.1016/j.cpcardiol.2020.100638
M3 - Review article
C2 - 32646544
AN - SCOPUS:85087477140
SN - 0146-2806
VL - 46
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 3
M1 - 100638
ER -