Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep

Hiroyuki Sakurai, Frank C. Schmalstieg, Lillian D. Traber, Hal K. Hawkins, Daniel L. Traber

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The effects of a monoclonal antibody against L-selectin [leukoctye adhesion molecule (LAM)1-3] on microvascular fluid flux were determined in conscious sheep subjected to a combined injury of 40% third-degree burn and smoke inhalation. This combined injury induced a rapid increase in systemic prefemoral lymph flow (sQ̇(lymph)) from the burned area and a delayed-onset increase in lung lymph flow. The initial increase in sQ̇(lymph) was associated with an elevation of the lymph-to-plasma oncotic pressure ratio; consequently, it leads to a predominant increase in the systemic soft tissue permeability index (sPI). In an untreated control group, the increased sPI was sustained beyond 24 h after injury. Pretreatment with LAM1-3 resulted in earlier recovery from. The increased sPI, although the initial responses in sQ(lymph) and sPI were identical to those in the nontreatment group. The delayed-onset lung permeability changes were significantly attenuated by pretreatment with LAM1-3. These findings indicate that both leukocyte- dependent and -independent mechanisms are involved in the pathogenesis that occurs after combined injury with burn and smoke inhalation.

Original languageEnglish (US)
Pages (from-to)1151-1159
Number of pages9
JournalJournal of Applied Physiology
Issue number4
StatePublished - Apr 1999


  • Fluid balance
  • Hemodynamics
  • Lung lymph
  • Sheep
  • Systemic prefemoral lymph

ASJC Scopus subject areas

  • General Medicine


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