Role of intramitochondrial nitric oxide in rat heart and kidney during hypertension

Leopoldo Aguilera-Aguirre, Juan Carlos González-Hernández, Victoriano Pérez-Vázquez, Joel Ramírez, Mónica Clemente-Guerrero, Rafael Villalobos-Molina, Alfredo Saavedra-Molina

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Nitric oxide (NO) is an important reactive molecule in many organisms. A mitochondrial nitric oxide synthase has been described; however, the role of NO in this organelle is not yet fully clear. We tested the effect of intramitochondrial NO on various functions from spontaneously hypertensive rats (SHR) and their normotensive genetic control. Wistar-Kyoto (WKY) rats. While the stimulation of intramitochondrial NOS increased calcium- and phosphate-induced permeability transition pore opening, its inhibition partially prevented it, without affecting membrane potential. Matrix free calcium and the pH decreased with NOS inhibition. Basal [NO] was lower in SHR than in WKY. Our data suggest that intramitochondrial NO plays an important role in mitochondrial regulation during hypertension.

Original languageEnglish (US)
Pages (from-to)413-423
Number of pages11
Issue number5
StatePublished - 2002
Externally publishedYes


  • Hypertension
  • Mitochondria
  • Nitric oxide
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Role of intramitochondrial nitric oxide in rat heart and kidney during hypertension'. Together they form a unique fingerprint.

Cite this