TY - JOUR
T1 - Role of interferon in leukocyte histamine release caused by common respiratory viruses
AU - Chonmaitree, Tasnee
AU - Lett-Brown, Michael A.
AU - Tsong, Yi
AU - Goldman, Armond S.
AU - Baron, Samuel
AU - Chonmaitree, Tasnee
N1 - Funding Information:
Received for publication I June 1987, and in revised form 20 August 1987. Informed consent was obtained from volunteer donors. All procedures conformed to the guidelines established by the U.S. Department of Health and Human Services and the University of Texas Medical Branch Institutional Review Board. This work was supported in part by grant RR-07205-06 from the Division of Research Resources and by a grant from the American Lung Association. We thank Dr. Caroline B. Hall for advice, Dr. Steven Greenberg and Dr. Robert F. Betts for providing the influenza and rhinovirus strains, and Linda Richardson and Joyce Sabados for technical assistance. Please address requests for reprints to Dr. Tasnee Chonmaitree, Department of Pediatrics, University of Texas Medical Branch, C-71, Galveston, Texas 77550. * Present address: Division of Biometrics, Food and Drug Administration, Rockville, Maryland.
PY - 1988/1
Y1 - 1988/1
N2 - Asthmatic attacks are often precipitated by viral respiratory infections. The mechanism of virus-induced asthma is still unclear. Interferon could be an important mediator in virus-induced hypersensitivity reactions, because interferon is induced by some respiratory viruses, and it can enhance IgE-mediated histamine release in vitro. We studied the effect of common respiratory viruses, including both interferon inducers and non-interferon inducers, on IgE-mediated leukocyte histamine release. Leukocytes from healthy, nonallergic donors were exposed to different strains of respiratory viruses, and basophils were challenged with antibody to IgE to release histamine. We found that the viruses are capable of enhancing IgE-mediated histamine release in the presence or absence of interferon. Our results suggest that although interferon may play a role in virus-induced hypersen- sivity reactions, other mechanisms probably also play a significant role.
AB - Asthmatic attacks are often precipitated by viral respiratory infections. The mechanism of virus-induced asthma is still unclear. Interferon could be an important mediator in virus-induced hypersensitivity reactions, because interferon is induced by some respiratory viruses, and it can enhance IgE-mediated histamine release in vitro. We studied the effect of common respiratory viruses, including both interferon inducers and non-interferon inducers, on IgE-mediated leukocyte histamine release. Leukocytes from healthy, nonallergic donors were exposed to different strains of respiratory viruses, and basophils were challenged with antibody to IgE to release histamine. We found that the viruses are capable of enhancing IgE-mediated histamine release in the presence or absence of interferon. Our results suggest that although interferon may play a role in virus-induced hypersen- sivity reactions, other mechanisms probably also play a significant role.
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U2 - 10.1093/infdis/157.1.127
DO - 10.1093/infdis/157.1.127
M3 - Article
C2 - 2447197
AN - SCOPUS:0023852252
SN - 0022-1899
VL - 157
SP - 127
EP - 132
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -