Role of IL-5 during primary and secondary immune response to acetylcholine receptor

Mathilde A. Poussin, Elzbieta Goluszko, Juan U. Franco, Premkumar Christadoss

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - 2002
Externally publishedYes


  • Autoimmunity
  • IL-5
  • IL-5 gene knockout
  • Immunomodulation
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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