Role of cGMP in hydrogen sulfide signaling

Sofia Iris Bibli, Guangdong Yang, Zongmin Zhou, Rui Wang, Stavros Topouzis, Andreas Papapetropoulos

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


The importance of hydrogen sulfide (H2S) in physiology and disease is being increasingly recognized in recent years. Unlike nitric oxide (NO) that signals mainly through soluble guanyl cyclase (sGC)/cGMP, H2S is more promiscuous, affecting multiple pathways. It interacts with ion channels, enzymes, transcription factors and receptors. It was originally reported that H2S does not alter the levels of cyclic nucleotides. More recent publications, however, have shown increases in intracellular cGMP following exposure of cells or tissues to exogenously administered or endogenously produced H2S. Herein, we discuss the evidence for the participation of cGMP in H2S signaling and reconcile the seemingly divergent results presented in the literature on the role of this cyclic nucleotide in the biological actions of H2S.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalNitric Oxide - Biology and Chemistry
StatePublished - Apr 30 2015
Externally publishedYes


  • Angiogenesis
  • Hydrogen sulfide
  • PKG
  • Relaxation
  • cGMP

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research


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