Rocky mountain spotted fever: Hepatic lesions in childhood cases

Mark D. Jackson; Celia Kirkman; William D. Bradford; David H. Walker

doi:10.3109/15513818609068864

Rocky mountain spotted fever: Hepatic lesions in childhood cases

Mark D. Jackson, Celia Kirkman, William D. Bradford, David H. Walker

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases..

Original language	English (US)
Pages (from-to)	379-388
Number of pages	10
Journal	Fetal and Pediatric Pathology
Volume	5
Issue number	3-4
DOIs	https://doi.org/10.3109/15513818609068864
State	Published - 1986
Externally published	Yes

Keywords

Immunofluorescence microscopyi
Light microscopy
Liver
Rickettsia rickettsii
Rocky mountain spotted fever

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.3109/15513818609068864

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title = "Rocky mountain spotted fever: Hepatic lesions in childhood cases",

abstract = "We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases..",

keywords = "Immunofluorescence microscopyi, Light microscopy, Liver, Rickettsia rickettsii, Rocky mountain spotted fever",

author = "Jackson, {Mark D.} and Celia Kirkman and Bradford, {William D.} and Walker, {David H.}",

year = "1986",

doi = "10.3109/15513818609068864",

language = "English (US)",

volume = "5",

pages = "379--388",

journal = "Fetal and Pediatric Pathology",

issn = "1551-3815",

publisher = "Informa Healthcare",

number = "3-4",

}

TY - JOUR

T1 - Rocky mountain spotted fever

T2 - Hepatic lesions in childhood cases

AU - Jackson, Mark D.

AU - Kirkman, Celia

AU - Bradford, William D.

AU - Walker, David H.

PY - 1986

Y1 - 1986

N2 - We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases..

AB - We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases..

KW - Immunofluorescence microscopyi

KW - Light microscopy

KW - Liver

KW - Rickettsia rickettsii

KW - Rocky mountain spotted fever

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U2 - 10.3109/15513818609068864

DO - 10.3109/15513818609068864

M3 - Article

C2 - 3537996

AN - SCOPUS:0022488038

SN - 1551-3815

VL - 5

SP - 379

EP - 388

JO - Fetal and Pediatric Pathology

JF - Fetal and Pediatric Pathology

IS - 3-4

ER -

Rocky mountain spotted fever: Hepatic lesions in childhood cases

Abstract

Keywords

ASJC Scopus subject areas

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