Risk factors for Nipah virus infection among abattoir workers in Singapore

Madeleine H.L. Chew; Paul M. Arguin; David K. Shay; Kee Tai Goh; Pierre E. Rollin; Wun Ju Shieh; Sherif R. Zaki; Paul A. Rota; Ai Ee Ling; Thomas G. Ksiazek; Suok Kai Chew; Larry J. Anderson

doi:10.1086/315443

Risk factors for Nipah virus infection among abattoir workers in Singapore

Madeleine H.L. Chew, Paul M. Arguin, David K. Shay, Kee Tai Goh, Pierre E. Rollin, Wun Ju Shieh, Sherif R. Zaki, Paul A. Rota, Ai Ee Ling, Thomas G. Ksiazek, Suok Kai Chew, Larry J. Anderson

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipah-virus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti- Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM. All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P = .01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.

Original language	English (US)
Pages (from-to)	1760-1763
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	181
Issue number	5
DOIs	https://doi.org/10.1086/315443
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1086/315443

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@article{a6d51543e1ab4c83948c4e53a4448e0a,

title = "Risk factors for Nipah virus infection among abattoir workers in Singapore",

abstract = "During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipah-virus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti- Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM. All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P = .01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.",

author = "Chew, {Madeleine H.L.} and Arguin, {Paul M.} and Shay, {David K.} and Goh, {Kee Tai} and Rollin, {Pierre E.} and Shieh, {Wun Ju} and Zaki, {Sherif R.} and Rota, {Paul A.} and Ling, {Ai Ee} and Ksiazek, {Thomas G.} and Chew, {Suok Kai} and Anderson, {Larry J.}",

year = "2000",

doi = "10.1086/315443",

language = "English (US)",

volume = "181",

pages = "1760--1763",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Risk factors for Nipah virus infection among abattoir workers in Singapore

AU - Chew, Madeleine H.L.

AU - Arguin, Paul M.

AU - Shay, David K.

AU - Goh, Kee Tai

AU - Rollin, Pierre E.

AU - Shieh, Wun Ju

AU - Zaki, Sherif R.

AU - Rota, Paul A.

AU - Ling, Ai Ee

AU - Ksiazek, Thomas G.

AU - Chew, Suok Kai

AU - Anderson, Larry J.

PY - 2000

Y1 - 2000

N2 - During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipah-virus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti- Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM. All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P = .01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.

AB - During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipah-virus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti- Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM. All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P = .01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.

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JO - Journal of Infectious Diseases

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IS - 5

ER -

Risk factors for Nipah virus infection among abattoir workers in Singapore

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