Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo

Daniel G. Bausch; Matthias Borchert; Thomas Grein; Cathy Roth; Robert Swanepoel; Modeste L. Libande; Antoine Talarmin; Eric Bertherat; Jean Jacques Muyembe-Tamfum; Ben Tugume; Robert Colebunders; Kader M. Kondé; Patricia Pirard; Loku L. Olinda; Guénaël R. Rodier; Patricia Campbell; Oyewale Tomori; Thomas G. Ksiazek; Pierre E. Rollin

doi:10.3201/eid0912.030355

Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo

Daniel G. Bausch, Matthias Borchert, Thomas Grein, Cathy Roth, Robert Swanepoel, Modeste L. Libande, Antoine Talarmin, Eric Bertherat, Jean Jacques Muyembe-Tamfum, Ben Tugume, Robert Colebunders, Kader M. Kondé, Patricia Pirard, Loku L. Olinda, Guénaël R. Rodier, Patricia Campbell, Oyewale Tomori, Thomas G. Ksiazek, Pierre E. Rollin

Research output: Contribution to journal › Review article › peer-review

111 Scopus citations

Abstract

We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus.

Original language	English (US)
Pages (from-to)	1531-1537
Number of pages	7
Journal	Emerging infectious diseases
Volume	9
Issue number	12
DOIs	https://doi.org/10.3201/eid0912.030355
State	Published - Dec 2003
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Bausch, D. G., Borchert, M., Grein, T., Roth, C., Swanepoel, R., Libande, M. L., Talarmin, A., Bertherat, E., Muyembe-Tamfum, J. J., Tugume, B., Colebunders, R., Kondé, K. M., Pirard, P., Olinda, L. L., Rodier, G. R., Campbell, P., Tomori, O., Ksiazek, T. G., & Rollin, P. E. (2003). Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo. Emerging infectious diseases, 9(12), 1531-1537. https://doi.org/10.3201/eid0912.030355

Bausch, DG, Borchert, M, Grein, T, Roth, C, Swanepoel, R, Libande, ML, Talarmin, A, Bertherat, E, Muyembe-Tamfum, JJ, Tugume, B, Colebunders, R, Kondé, KM, Pirard, P, Olinda, LL, Rodier, GR, Campbell, P, Tomori, O, Ksiazek, TG & Rollin, PE 2003, 'Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo', Emerging infectious diseases, vol. 9, no. 12, pp. 1531-1537. https://doi.org/10.3201/eid0912.030355

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abstract = "We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus.",

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AU - Libande, Modeste L.

AU - Talarmin, Antoine

AU - Bertherat, Eric

AU - Muyembe-Tamfum, Jean Jacques

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AU - Colebunders, Robert

AU - Kondé, Kader M.

AU - Pirard, Patricia

AU - Olinda, Loku L.

AU - Rodier, Guénaël R.

AU - Campbell, Patricia

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AU - Ksiazek, Thomas G.

AU - Rollin, Pierre E.

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AB - We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus.

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Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo

Abstract

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