Rift valley fever infection of rhesus monkeys: Implications for rapid diagnosis of human disease

J. C. Morrill; F. K. Knauert; T. G. Ksiazek; J. M. Meegan; C. J. Peters

doi:10.1016/S0923-2516(89)80091-3

Rift valley fever infection of rhesus monkeys: Implications for rapid diagnosis of human disease

J. C. Morrill, F. K. Knauert, T. G. Ksiazek, J. M. Meegan, C. J. Peters

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Rhesus monkeys inoculated with Rift Valley fever (RVF) virus provide a model in which serial observations of serum viral antigen and antibodies can be made. In 9 non-fatal and 3 fatal infections, either antigen or IgM enzymelinked immunosorbent assay (ELISA) antibodies were detected in every serum sample during the acute phase. Furthermore, viral nucleic acid could be detected by filter hybridization in most samples taken on days 1 to 3. Circulation of significant quantities of viral RNA provides an additional approach to the diagnosis and study of RVF.

Original language	English (US)
Pages (from-to)	139-146
Number of pages	8
Journal	Research in Virology
Volume	140
Issue number	C
DOIs	https://doi.org/10.1016/S0923-2516(89)80091-3
State	Published - 1989
Externally published	Yes

Keywords

DNA hybridization
ELISA
Models
RVF
Rhesus monkey

ASJC Scopus subject areas

Immunology
Virology

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10.1016/S0923-2516(89)80091-3

Cite this

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title = "Rift valley fever infection of rhesus monkeys: Implications for rapid diagnosis of human disease",

abstract = "Rhesus monkeys inoculated with Rift Valley fever (RVF) virus provide a model in which serial observations of serum viral antigen and antibodies can be made. In 9 non-fatal and 3 fatal infections, either antigen or IgM enzymelinked immunosorbent assay (ELISA) antibodies were detected in every serum sample during the acute phase. Furthermore, viral nucleic acid could be detected by filter hybridization in most samples taken on days 1 to 3. Circulation of significant quantities of viral RNA provides an additional approach to the diagnosis and study of RVF.",

keywords = "DNA hybridization, ELISA, Models, RVF, Rhesus monkey",

author = "Morrill, {J. C.} and Knauert, {F. K.} and Ksiazek, {T. G.} and Meegan, {J. M.} and Peters, {C. J.}",

year = "1989",

doi = "10.1016/S0923-2516(89)80091-3",

language = "English (US)",

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pages = "139--146",

journal = "Research in Virology",

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T1 - Rift valley fever infection of rhesus monkeys

T2 - Implications for rapid diagnosis of human disease

AU - Morrill, J. C.

AU - Knauert, F. K.

AU - Ksiazek, T. G.

AU - Meegan, J. M.

AU - Peters, C. J.

PY - 1989

Y1 - 1989

N2 - Rhesus monkeys inoculated with Rift Valley fever (RVF) virus provide a model in which serial observations of serum viral antigen and antibodies can be made. In 9 non-fatal and 3 fatal infections, either antigen or IgM enzymelinked immunosorbent assay (ELISA) antibodies were detected in every serum sample during the acute phase. Furthermore, viral nucleic acid could be detected by filter hybridization in most samples taken on days 1 to 3. Circulation of significant quantities of viral RNA provides an additional approach to the diagnosis and study of RVF.

AB - Rhesus monkeys inoculated with Rift Valley fever (RVF) virus provide a model in which serial observations of serum viral antigen and antibodies can be made. In 9 non-fatal and 3 fatal infections, either antigen or IgM enzymelinked immunosorbent assay (ELISA) antibodies were detected in every serum sample during the acute phase. Furthermore, viral nucleic acid could be detected by filter hybridization in most samples taken on days 1 to 3. Circulation of significant quantities of viral RNA provides an additional approach to the diagnosis and study of RVF.

KW - DNA hybridization

KW - ELISA

KW - Models

KW - RVF

KW - Rhesus monkey

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DO - 10.1016/S0923-2516(89)80091-3

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AN - SCOPUS:0024498758

SN - 0923-2516

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JO - Research in Virology

JF - Research in Virology

IS - C

ER -

Rift valley fever infection of rhesus monkeys: Implications for rapid diagnosis of human disease

Abstract

Keywords

ASJC Scopus subject areas

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