@article{d52246a1502e419ca7523aa11e9c8319,
title = "Rickettsial infection of the pulmonary microcirculation: The basis for interstitial pneumonitis in Rocky Mountain spotted fever",
abstract = "Pulmonary tissue from 10 patients with fatal Rocky Mountain spotted fever was examined by brightfield microscopy for histopathologic lesions and by immunofluorescence for Rickettsia rickettsii. The distribution of rickettsiae and the vasculitis of the pulmonary microcirculation coincided. The lungs demonstrated the consequent interstitial pneumonia-alveolar septal congestion and interstitial edema; alveolar edema, fibrin, macrophages, and hemorrhage; and interlobular septal edema. The effects of the rickettsial damage to the pulmonary microcirculation are an important component of the pathophysiology of severe Rocky Mountain spotted fever. The distribution of rickettsial organisms within the lung indicates that person to person aerosol transmission is extremely unlikely.",
author = "Walker, {David H.} and Crawford, {Cynthia G.} and Cain, {Barbara G.}",
note = "Funding Information: Sections of fi)rmalin fixed, paraffin embedded blocks of lung were sectioned at 5 p.m. thickness and processed for routine hematoxylin-eosin stain, phosphotungstic acld-hematoxylin stain, Verhoeff-van Gieson stain, Masson's tr!chrome, and specific direct imnmnofluorescent demonstration of Rickettsia rickettsii. The technique for immtmofluorescence Accepted for publicationJ anuary 2, 1979. *Stud)' supported by tile Trust Fund of tile Departinent of Patholog){"} of tile University of North Carolina. tAssistant Professor. Department of Pathology, University of North Carolina School of Medicine. Assistant Pathologist, North Carolina Memorial Hospital, Chapel Hill, North Carolina. +Fourth Year Student, Universityo f North Carolina School of Medicine. Chapel llill. North Carolina. w Assistant. Department of I'atholog)'. Universityo f North Carolina School of Medicine, Chapel Hill, North Carolina. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1980",
month = may,
doi = "10.1016/S0046-8177(80)80008-6",
language = "English (US)",
volume = "11",
pages = "263--272",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "3",
}