Rheumatologic and skeletal changes in acromegaly

S. A. Lieberman, A. G. Bjorkengren, A. R. Hoffman

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


The anabolic functions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in cartilage and bone metabolism are important in the normal physiology of these tissues. The effects of chronic elevation of GH and IGF-I levels on bony structures produce the typical physical changes associated with acromegaly, whereas the effects on cartilage result in arthropathy, which is usually degenerative. This article presents an overview of the physiologic roles of GH and IGF-I in cartilage and bone metabolism, the clinical features of the degenerative arthropathy and other rheumatologic syndromes associated with acromegaly, effects of acromegaly on bone and mineral metabolism, and an unusual bone disease that is occasionally associated with acromegaly, the McCune-Albright syndrome.

Original languageEnglish (US)
Pages (from-to)615-631
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Issue number3
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Rheumatologic and skeletal changes in acromegaly'. Together they form a unique fingerprint.

Cite this