Review: HCG, preeclampsia and regulatory T cells

W. Norris, T. Nevers, S. Sharma, S. Kalkunte

Research output: Contribution to journalArticlepeer-review

Abstract

Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown. Marked by insufficient trophoblast invasion and poor spiral artery remodeling, preeclampsia has also been linked to immune dysregulation. Here we discuss the roles of hCG in the context of endovascular cross-talk between trophoblasts and endothelial cells and immune tolerance. We propose that functional and glycosylation modifications of hCG may contribute to the pathogenesis of preeclampsia.

Original languageEnglish (US)
Pages (from-to)S182-S185
JournalPlacenta
Volume32
Issue numberSUPPL. 2
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Angiogenesis
  • Human chorionic gonadotropin
  • Preeclampsia
  • T regulatory cells
  • Uterine natural killer cells

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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