Restoration of suppressed immunity in burned mice with cimetidine

R. Zapata-Sirvent, J. F. Hansbrough, V. Peterson, X. W. Wang, H. Claman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Thermal injury has shown to result in suppression of many aspects of immunity. We studied the effect of cimetidine on suppressed cell mediated immunity in burned mice, utilizing a method of quantitating sensitivity to the contact antigen, 2.4-dinitrofluorobenzene. Daily administration of cimetidine resulted in maintenance of normal cell mediated immunity in these otherwise immuno-suppressed animals. This effect may be secondary to the antagonism of cimetidine with histamine H2 receptors on suppressor cells. Immunorestoration with cimetidine may improve resistance of the burned host to infectious emplications.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalChinese Medical Journal
Issue number5
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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