Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

Robert J. Hogan; Guangping Gao; Thomas Rowe; Peter Bell; Douglas Flieder; Jason Paragas; Gary P. Kobinger; Nelson A. Wivel; Ronald G. Crystal; Julie Boyer; Heinz Feldmann; Thomas G. Voss; James M. Wilson

doi:10.1128/JVI.78.20.11416-11421.2004

Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

Robert J. Hogan, Guangping Gao, Thomas Rowe, Peter Bell, Douglas Flieder, Jason Paragas, Gary P. Kobinger, Nelson A. Wivel, Ronald G. Crystal, Julie Boyer, Heinz Feldmann, Thomas G. Voss, James M. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the tangs and the development of self-limited broachiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus an lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

Original language	English (US)
Pages (from-to)	11416-11421
Number of pages	6
Journal	Journal of virology
Volume	78
Issue number	20
DOIs	https://doi.org/10.1128/JVI.78.20.11416-11421.2004
State	Published - Oct 2004
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.78.20.11416-11421.2004

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Hogan, R. J., Gao, G., Rowe, T., Bell, P., Flieder, D., Paragas, J., Kobinger, G. P., Wivel, N. A., Crystal, R. G., Boyer, J., Feldmann, H., Voss, T. G., & Wilson, J. M. (2004). Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. Journal of virology, 78(20), 11416-11421. https://doi.org/10.1128/JVI.78.20.11416-11421.2004

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title = "Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1",

abstract = "Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the tangs and the development of self-limited broachiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus an lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.",

author = "Hogan, {Robert J.} and Guangping Gao and Thomas Rowe and Peter Bell and Douglas Flieder and Jason Paragas and Kobinger, {Gary P.} and Wivel, {Nelson A.} and Crystal, {Ronald G.} and Julie Boyer and Heinz Feldmann and Voss, {Thomas G.} and Wilson, {James M.}",

year = "2004",

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doi = "10.1128/JVI.78.20.11416-11421.2004",

language = "English (US)",

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T1 - Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

AU - Hogan, Robert J.

AU - Gao, Guangping

AU - Rowe, Thomas

AU - Bell, Peter

AU - Flieder, Douglas

AU - Paragas, Jason

AU - Kobinger, Gary P.

AU - Wivel, Nelson A.

AU - Crystal, Ronald G.

AU - Boyer, Julie

AU - Feldmann, Heinz

AU - Voss, Thomas G.

AU - Wilson, James M.

PY - 2004/10

Y1 - 2004/10

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AB - Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the tangs and the development of self-limited broachiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus an lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

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Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

Abstract

ASJC Scopus subject areas

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