TY - JOUR
T1 - Resistin
T2 - An inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome
AU - Abate, Nicola
AU - Sallam, Hanaa S.
AU - Rizzo, Manfredi
AU - Nikolic, Dragana
AU - Obradovic, Milan
AU - Bjelogrlic, Predrag
AU - Isenovic, Esma R.
PY - 2014
Y1 - 2014
N2 - Resistin is an adipocyte- and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.
AB - Resistin is an adipocyte- and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.
KW - Cardiovascular diseases
KW - Metabolic syndrome
KW - Resistin
KW - Type 2 diabetes
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U2 - 10.2174/1381612819666131206103102
DO - 10.2174/1381612819666131206103102
M3 - Review article
C2 - 24320036
AN - SCOPUS:84906256655
SN - 1381-6128
VL - 20
SP - 4961
EP - 4969
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 31
ER -