Abstract
Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.
Original language | English (US) |
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Article number | e01142-19 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 63 |
Issue number | 9 |
DOIs | |
State | Published - 2019 |
Keywords
- Antiviral
- Ebola virus
- Ebola virus disease
- Quinacrine
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases