Replication of Colorado tick fever virus within human hematopoietic progenitor cells

Claire S. Philipp; Carey Callaway; May C. Chu; Guo Hui Huang; Thomas P. Monath; Dennis Trent; Bruce L. Evatt

Replication of Colorado tick fever virus within human hematopoietic progenitor cells

Claire S. Philipp, Carey Callaway, May C. Chu, Guo Hui Huang, Thomas P. Monath, Dennis Trent, Bruce L. Evatt

Research output: Contribution to journal › Article › peer-review

Abstract

Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34⁺ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

Original language	English (US)
Pages (from-to)	2389-2395
Number of pages	7
Journal	Journal of virology
Volume	67
Issue number	4
State	Published - Apr 1993
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Cite this

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title = "Replication of Colorado tick fever virus within human hematopoietic progenitor cells",

abstract = "Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.",

author = "Philipp, {Claire S.} and Carey Callaway and Chu, {May C.} and Huang, {Guo Hui} and Monath, {Thomas P.} and Dennis Trent and Evatt, {Bruce L.}",

year = "1993",

month = apr,

language = "English (US)",

volume = "67",

pages = "2389--2395",

journal = "Journal of virology",

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T1 - Replication of Colorado tick fever virus within human hematopoietic progenitor cells

AU - Philipp, Claire S.

AU - Callaway, Carey

AU - Chu, May C.

AU - Huang, Guo Hui

AU - Monath, Thomas P.

AU - Trent, Dennis

AU - Evatt, Bruce L.

PY - 1993/4

Y1 - 1993/4

N2 - Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

AB - Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

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M3 - Article

C2 - 8445735

AN - SCOPUS:0027523236

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VL - 67

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JO - Journal of virology

JF - Journal of virology

IS - 4

ER -

Replication of Colorado tick fever virus within human hematopoietic progenitor cells

Abstract

ASJC Scopus subject areas

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