Renal candidiasis in the rat: effects of ureteral obstruction and diabetes

W. F. Tarry; T. S. Kowalkowski; M. A. Fisher

doi:10.1007/BF00510528

Renal candidiasis in the rat: effects of ureteral obstruction and diabetes

W. F. Tarry, T. S. Kowalkowski, M. A. Fisher

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of ureteral obstruction on the course of renal candidiasis in a rat model was studied, using both normal and diabetic Sprague-Dawley rats, and a clinical isolate of Candida albicans. Diabetes was induced by streptozotocin injection 1 week prior to inoculation and transabdominal ligation of the left ureter. On day 9 post inoculation, mean titers of Candida were similar in right and left kidneys of obstructed rats. Mean left renal titers for obstructed and control rats were similar (log₁₀ 2.68 CFU/g±0.73 (SE) vs. log₁₀ 2.21±0.09, P>0.01). Diabetes produced higher renal titers of Candida, regardless of the presence of ureteral obstruction (log₁₀ 5.74 CFU/g±0.57 (SE) vs. log₁₀ 2.21±0.09, P<0.01). Animals treated for one week with amphotericin B showed a marked difference in Candida titers between obstructed and control animals (log₁₀ 4.14 CFU/g±0.45 (SE) vs. 1.57±0.38) for both kidneys, and between obstructed and nonobstructed kidneys in the same animals.

Original language	English (US)
Pages (from-to)	367-370
Number of pages	4
Journal	Urological Research
Volume	17
Issue number	6
DOIs	https://doi.org/10.1007/BF00510528
State	Published - Nov 1989
Externally published	Yes

Keywords

Candidiasis
Diabetes
Ureteral obstruction

ASJC Scopus subject areas

Urology

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10.1007/BF00510528

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title = "Renal candidiasis in the rat: effects of ureteral obstruction and diabetes",

abstract = "The effect of ureteral obstruction on the course of renal candidiasis in a rat model was studied, using both normal and diabetic Sprague-Dawley rats, and a clinical isolate of Candida albicans. Diabetes was induced by streptozotocin injection 1 week prior to inoculation and transabdominal ligation of the left ureter. On day 9 post inoculation, mean titers of Candida were similar in right and left kidneys of obstructed rats. Mean left renal titers for obstructed and control rats were similar (log10 2.68 CFU/g±0.73 (SE) vs. log10 2.21±0.09, P>0.01). Diabetes produced higher renal titers of Candida, regardless of the presence of ureteral obstruction (log10 5.74 CFU/g±0.57 (SE) vs. log10 2.21±0.09, P<0.01). Animals treated for one week with amphotericin B showed a marked difference in Candida titers between obstructed and control animals (log10 4.14 CFU/g±0.45 (SE) vs. 1.57±0.38) for both kidneys, and between obstructed and nonobstructed kidneys in the same animals.",

keywords = "Candidiasis, Diabetes, Ureteral obstruction",

author = "Tarry, {W. F.} and Kowalkowski, {T. S.} and Fisher, {M. A.}",

year = "1989",

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doi = "10.1007/BF00510528",

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T2 - effects of ureteral obstruction and diabetes

AU - Tarry, W. F.

AU - Kowalkowski, T. S.

AU - Fisher, M. A.

PY - 1989/11

Y1 - 1989/11

N2 - The effect of ureteral obstruction on the course of renal candidiasis in a rat model was studied, using both normal and diabetic Sprague-Dawley rats, and a clinical isolate of Candida albicans. Diabetes was induced by streptozotocin injection 1 week prior to inoculation and transabdominal ligation of the left ureter. On day 9 post inoculation, mean titers of Candida were similar in right and left kidneys of obstructed rats. Mean left renal titers for obstructed and control rats were similar (log10 2.68 CFU/g±0.73 (SE) vs. log10 2.21±0.09, P>0.01). Diabetes produced higher renal titers of Candida, regardless of the presence of ureteral obstruction (log10 5.74 CFU/g±0.57 (SE) vs. log10 2.21±0.09, P<0.01). Animals treated for one week with amphotericin B showed a marked difference in Candida titers between obstructed and control animals (log10 4.14 CFU/g±0.45 (SE) vs. 1.57±0.38) for both kidneys, and between obstructed and nonobstructed kidneys in the same animals.

AB - The effect of ureteral obstruction on the course of renal candidiasis in a rat model was studied, using both normal and diabetic Sprague-Dawley rats, and a clinical isolate of Candida albicans. Diabetes was induced by streptozotocin injection 1 week prior to inoculation and transabdominal ligation of the left ureter. On day 9 post inoculation, mean titers of Candida were similar in right and left kidneys of obstructed rats. Mean left renal titers for obstructed and control rats were similar (log10 2.68 CFU/g±0.73 (SE) vs. log10 2.21±0.09, P>0.01). Diabetes produced higher renal titers of Candida, regardless of the presence of ureteral obstruction (log10 5.74 CFU/g±0.57 (SE) vs. log10 2.21±0.09, P<0.01). Animals treated for one week with amphotericin B showed a marked difference in Candida titers between obstructed and control animals (log10 4.14 CFU/g±0.45 (SE) vs. 1.57±0.38) for both kidneys, and between obstructed and nonobstructed kidneys in the same animals.

KW - Candidiasis

KW - Diabetes

KW - Ureteral obstruction

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Renal candidiasis in the rat: effects of ureteral obstruction and diabetes

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Keywords

ASJC Scopus subject areas

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