Renal artery stenosis in kidney transplants: Assessment of the risk factors

Jalal Etemadi; Khosro Rahbar; Ali Nobakht Haghighi; Nazila Bagheri; Kianoosh Falaknazi; Mohammad Reza Ardalan; Kamyar Ghabili; Mohammadali M. Shoja

doi:10.2147/VHRM.S19645

Renal artery stenosis in kidney transplants: Assessment of the risk factors

Jalal Etemadi, Khosro Rahbar, Ali Nobakht Haghighi, Nazila Bagheri, Kianoosh Falaknazi, Mohammad Reza Ardalan, Kamyar Ghabili, Mohammadali M. Shoja

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Transplant renal artery stenosis (TRAS) is an important cause of hypertension and renal allograft dysfunction occurring in kidney transplant recipients. However, conflicting predisposing risk factors for TRAS have been reported in the literature. Objective: The aim of the present study was to assess the potential correlation between possible risk factors and TRAS in a group of living donor renal transplant recipients 1 year after the renal transplantation. Methods: We evaluated the presence of renal artery stenosis in 16 recipients who presented with refractory hypertension and/or allograft dysfunction 1 year after renal transplantation. Screening for TRAS was made by magnetic resonance angiography and diagnosis was confirmed by conventional renal angiography. Age, gender, history of acute rejection, plasma lipid profile, serum creatinine, blood urea nitrogen, serum uric acid, calcium phosphate (CaPO₄) product, alkaline phosphatase, fasting blood sugar, hemoglobin, and albumin were compared between the TRAS and non-TRAS groups. Results: Of 16 kidney transplant recipients, TRAS was diagnosed in three patients (two men and one woman). High levels of calcium, phosphorous, CaPO₄ product, and low-density lipoprotein (LDL) cholesterol were significantly correlated with the risk of TRAS 1 year after renal transplantation (P < 0.05). Serum level of uric acid tended to have a significant correlation (P = 0.051). Conclusion: Correlation between high CaPO₄ product, LDL cholesterol, and perhaps uric acid and TRAS in living donor renal transplant recipients 1 year after renal transplantation might suggest the importance of early detection and tight control of these potential risk factors.

Original language	English (US)
Pages (from-to)	503-507
Number of pages	5
Journal	Vascular Health and Risk Management
Volume	7
Issue number	1
DOIs	https://doi.org/10.2147/VHRM.S19645
State	Published - 2011
Externally published	Yes

Keywords

Atherosclerosis
Calcium phosphate product
Low density lipoprotein
Transplant renal artery stenosis
Uric acid

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Cardiology and Cardiovascular Medicine
Pharmacology (medical)
Hematology
Endocrinology, Diabetes and Metabolism

Access to Document

10.2147/VHRM.S19645

Cite this

@article{c0f74c8c96f14ca8b264e89faee03a47,

title = "Renal artery stenosis in kidney transplants: Assessment of the risk factors",

abstract = "Background: Transplant renal artery stenosis (TRAS) is an important cause of hypertension and renal allograft dysfunction occurring in kidney transplant recipients. However, conflicting predisposing risk factors for TRAS have been reported in the literature. Objective: The aim of the present study was to assess the potential correlation between possible risk factors and TRAS in a group of living donor renal transplant recipients 1 year after the renal transplantation. Methods: We evaluated the presence of renal artery stenosis in 16 recipients who presented with refractory hypertension and/or allograft dysfunction 1 year after renal transplantation. Screening for TRAS was made by magnetic resonance angiography and diagnosis was confirmed by conventional renal angiography. Age, gender, history of acute rejection, plasma lipid profile, serum creatinine, blood urea nitrogen, serum uric acid, calcium phosphate (CaPO4) product, alkaline phosphatase, fasting blood sugar, hemoglobin, and albumin were compared between the TRAS and non-TRAS groups. Results: Of 16 kidney transplant recipients, TRAS was diagnosed in three patients (two men and one woman). High levels of calcium, phosphorous, CaPO4 product, and low-density lipoprotein (LDL) cholesterol were significantly correlated with the risk of TRAS 1 year after renal transplantation (P < 0.05). Serum level of uric acid tended to have a significant correlation (P = 0.051). Conclusion: Correlation between high CaPO4 product, LDL cholesterol, and perhaps uric acid and TRAS in living donor renal transplant recipients 1 year after renal transplantation might suggest the importance of early detection and tight control of these potential risk factors.",

keywords = "Atherosclerosis, Calcium phosphate product, Low density lipoprotein, Transplant renal artery stenosis, Uric acid",

author = "Jalal Etemadi and Khosro Rahbar and Haghighi, {Ali Nobakht} and Nazila Bagheri and Kianoosh Falaknazi and Ardalan, {Mohammad Reza} and Kamyar Ghabili and Shoja, {Mohammadali M.}",

year = "2011",

doi = "10.2147/VHRM.S19645",

language = "English (US)",

volume = "7",

pages = "503--507",

journal = "Vascular Health and Risk Management",

issn = "1176-6344",

publisher = "Dove Medical Press Ltd.",

number = "1",

}

TY - JOUR

T1 - Renal artery stenosis in kidney transplants

T2 - Assessment of the risk factors

AU - Etemadi, Jalal

AU - Rahbar, Khosro

AU - Haghighi, Ali Nobakht

AU - Bagheri, Nazila

AU - Falaknazi, Kianoosh

AU - Ardalan, Mohammad Reza

AU - Ghabili, Kamyar

AU - Shoja, Mohammadali M.

PY - 2011

Y1 - 2011

N2 - Background: Transplant renal artery stenosis (TRAS) is an important cause of hypertension and renal allograft dysfunction occurring in kidney transplant recipients. However, conflicting predisposing risk factors for TRAS have been reported in the literature. Objective: The aim of the present study was to assess the potential correlation between possible risk factors and TRAS in a group of living donor renal transplant recipients 1 year after the renal transplantation. Methods: We evaluated the presence of renal artery stenosis in 16 recipients who presented with refractory hypertension and/or allograft dysfunction 1 year after renal transplantation. Screening for TRAS was made by magnetic resonance angiography and diagnosis was confirmed by conventional renal angiography. Age, gender, history of acute rejection, plasma lipid profile, serum creatinine, blood urea nitrogen, serum uric acid, calcium phosphate (CaPO4) product, alkaline phosphatase, fasting blood sugar, hemoglobin, and albumin were compared between the TRAS and non-TRAS groups. Results: Of 16 kidney transplant recipients, TRAS was diagnosed in three patients (two men and one woman). High levels of calcium, phosphorous, CaPO4 product, and low-density lipoprotein (LDL) cholesterol were significantly correlated with the risk of TRAS 1 year after renal transplantation (P < 0.05). Serum level of uric acid tended to have a significant correlation (P = 0.051). Conclusion: Correlation between high CaPO4 product, LDL cholesterol, and perhaps uric acid and TRAS in living donor renal transplant recipients 1 year after renal transplantation might suggest the importance of early detection and tight control of these potential risk factors.

AB - Background: Transplant renal artery stenosis (TRAS) is an important cause of hypertension and renal allograft dysfunction occurring in kidney transplant recipients. However, conflicting predisposing risk factors for TRAS have been reported in the literature. Objective: The aim of the present study was to assess the potential correlation between possible risk factors and TRAS in a group of living donor renal transplant recipients 1 year after the renal transplantation. Methods: We evaluated the presence of renal artery stenosis in 16 recipients who presented with refractory hypertension and/or allograft dysfunction 1 year after renal transplantation. Screening for TRAS was made by magnetic resonance angiography and diagnosis was confirmed by conventional renal angiography. Age, gender, history of acute rejection, plasma lipid profile, serum creatinine, blood urea nitrogen, serum uric acid, calcium phosphate (CaPO4) product, alkaline phosphatase, fasting blood sugar, hemoglobin, and albumin were compared between the TRAS and non-TRAS groups. Results: Of 16 kidney transplant recipients, TRAS was diagnosed in three patients (two men and one woman). High levels of calcium, phosphorous, CaPO4 product, and low-density lipoprotein (LDL) cholesterol were significantly correlated with the risk of TRAS 1 year after renal transplantation (P < 0.05). Serum level of uric acid tended to have a significant correlation (P = 0.051). Conclusion: Correlation between high CaPO4 product, LDL cholesterol, and perhaps uric acid and TRAS in living donor renal transplant recipients 1 year after renal transplantation might suggest the importance of early detection and tight control of these potential risk factors.

KW - Atherosclerosis

KW - Calcium phosphate product

KW - Low density lipoprotein

KW - Transplant renal artery stenosis

KW - Uric acid

UR - http://www.scopus.com/inward/record.url?scp=84856054344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856054344&partnerID=8YFLogxK

U2 - 10.2147/VHRM.S19645

DO - 10.2147/VHRM.S19645

M3 - Article

C2 - 21915167

AN - SCOPUS:84856054344

SN - 1176-6344

VL - 7

SP - 503

EP - 507

JO - Vascular Health and Risk Management

JF - Vascular Health and Risk Management

IS - 1

ER -

Renal artery stenosis in kidney transplants: Assessment of the risk factors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this