Regulation of transcription factors via natural decoys in genomic DNA

Catherine A. Kemme; Dan Nguyen; Abhijnan Chattopadhyay; Junji Iwahara

doi:10.1080/21541264.2016.1188873

Regulation of transcription factors via natural decoys in genomic DNA

Catherine A. Kemme, Dan Nguyen, Abhijnan Chattopadhyay, Junji Iwahara

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	Transcription
Volume	7
Issue number	4
DOIs	https://doi.org/10.1080/21541264.2016.1188873
State	Published - Aug 7 2016

Keywords

decoy
regulatory elements
sequestration
target search
transcription factors

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2016.1188873

Cite this

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AU - Nguyen, Dan

AU - Chattopadhyay, Abhijnan

AU - Iwahara, Junji

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AB - Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.

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KW - target search

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Regulation of transcription factors via natural decoys in genomic DNA

Abstract

Keywords

ASJC Scopus subject areas

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