Abstract
Several dietary factors influence the oxidative metabolism of chemicals in humans. Increasing the ratio of protein to carbohydrate or fat in the diet, feeding cabbage and brussels sprouts or feeding charcoal-broiled beef for several days stimulates human drug metabolism. The chronic ingestion of ethanol stimulates drug metabolism whereas the chronic ingestion of methylxanthine-containing foods inhibits drug metabolism. In contrast, an increase in the ratio of fat to carbohydrate in the diet of normal subjects or the fasting of obese individuals for several days has little or no effect on drug metabolism. Flavonoids in edible plants influence the metabolism of foreign chemicals by human liver in vitro. The addition of flavone, tangeretin or nobiletin to human liver microsomes activates both the hydroxylation of benzo[a]pyrene and the metabolism of aflatoxin B1 to mutagens. On the other hand, quercetin, kaempferol, morin and chrysin, which are also normally occurring flavonoids, inhibit the hydroxylation of benzo[a]pyrene by human liver microsomes.
Original language | English (US) |
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Title of host publication | Environmental Chemicals, Enzyme Function and Human Disease |
Publisher | John Wiley and Sons Ltd. |
Pages | 147-162 |
Number of pages | 16 |
ISBN (Electronic) | 9780470720592 |
ISBN (Print) | 0444901574, 9780444901576 |
DOIs | |
State | Published - May 30 2008 |
Externally published | Yes |
Keywords
- Chemicals
- Chronic ingestion
- Human drug metabolism
- Human liver mocrosomes
- Hydroxylation
ASJC Scopus subject areas
- General Medicine