Regulation of gastric acid secretion by secretin and serotonin

Laszio Mate, Tsuguo Sakamoto, George H. Greeley, James C. Thompson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or secretin alone significantly inhibited pentagastrin-induced gastric acid secretion. The combined administration of serotonin and secretin inhibited gastric acid secretion to a greater magnitude than either secretagogue alone. The administration of methysergide diminished basal concentrations of secretin and abolished the inhibitory effect of secretin on gastric acid secretion. Methysergide also enhanced the stimulatory activity of pentagastrin-induced gastric acid secretion. The inhibitory action of intraduodenal acidification of pentagastrin-induced gastric acid secretion was reversed by methysergide.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalThe American Journal of Surgery
Issue number1
StatePublished - Jan 1985
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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