Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

R. M. Kinney; J. J. Esposito; J. H. Mathews; B. J.B. Johnson; J. T. Roehrig; A. D.T. Barrett; D. W. Trent

doi:10.1128/jvi.62.12.4697-4702.1988

Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

R. M. Kinney, J. J. Esposito, J. H. Mathews, B. J.B. Johnson, J. T. Roehrig, A. D.T. Barrett, D. W. Trent

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

Original language	English (US)
Pages (from-to)	4697-4702
Number of pages	6
Journal	Journal of virology
Volume	62
Issue number	12
DOIs	https://doi.org/10.1128/jvi.62.12.4697-4702.1988
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.62.12.4697-4702.1988

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title = "Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge",

abstract = "Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.",

author = "Kinney, {R. M.} and Esposito, {J. J.} and Mathews, {J. H.} and Johnson, {B. J.B.} and Roehrig, {J. T.} and Barrett, {A. D.T.} and Trent, {D. W.}",

year = "1988",

doi = "10.1128/jvi.62.12.4697-4702.1988",

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T1 - Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

AU - Kinney, R. M.

AU - Esposito, J. J.

AU - Mathews, J. H.

AU - Johnson, B. J.B.

AU - Roehrig, J. T.

AU - Barrett, A. D.T.

AU - Trent, D. W.

PY - 1988

Y1 - 1988

N2 - Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

AB - Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

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Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

Abstract

ASJC Scopus subject areas

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