Recent insight into autophagy and immunity at the maternal-fetal interface

Yuanyao Chen; Lin Xiao; Jia Xu; Jingming Wang; Zhiquan Yu; Kai Zhao; Huiping Zhang; Shibin Cheng; Surendra Sharma; Aihua Liao; Chunyan Liu

doi:10.1016/j.jri.2022.103781

Recent insight into autophagy and immunity at the maternal-fetal interface

Yuanyao Chen, Lin Xiao, Jia Xu, Jingming Wang, Zhiquan Yu, Kai Zhao, Huiping Zhang, Shibin Cheng, Surendra Sharma, Aihua Liao, Chunyan Liu

Research output: Contribution to journal › Review article › peer-review

Abstract

Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects.

Original language	English (US)
Article number	103781
Journal	Journal of Reproductive Immunology
Volume	155
DOIs	https://doi.org/10.1016/j.jri.2022.103781
State	Published - Feb 2023
Externally published	Yes

Keywords

Autophagy
adaptive immunity
immune tolerance molecules
innate immunity
maternal-fetal interface

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.jri.2022.103781

Cite this

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title = "Recent insight into autophagy and immunity at the maternal-fetal interface",

abstract = "Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects.",

keywords = "Autophagy, adaptive immunity, immune tolerance molecules, innate immunity, maternal-fetal interface",

author = "Yuanyao Chen and Lin Xiao and Jia Xu and Jingming Wang and Zhiquan Yu and Kai Zhao and Huiping Zhang and Shibin Cheng and Surendra Sharma and Aihua Liao and Chunyan Liu",

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year = "2023",

month = feb,

doi = "10.1016/j.jri.2022.103781",

language = "English (US)",

volume = "155",

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T1 - Recent insight into autophagy and immunity at the maternal-fetal interface

AU - Chen, Yuanyao

AU - Xiao, Lin

AU - Xu, Jia

AU - Wang, Jingming

AU - Yu, Zhiquan

AU - Zhao, Kai

AU - Zhang, Huiping

AU - Cheng, Shibin

AU - Sharma, Surendra

AU - Liao, Aihua

AU - Liu, Chunyan

PY - 2023/2

Y1 - 2023/2

N2 - Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects.

AB - Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects.

KW - Autophagy

KW - adaptive immunity

KW - immune tolerance molecules

KW - innate immunity

KW - maternal-fetal interface

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DO - 10.1016/j.jri.2022.103781

M3 - Review article

C2 - 36463798

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SN - 0165-0378

VL - 155

JO - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

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ER -

Recent insight into autophagy and immunity at the maternal-fetal interface

Abstract

Keywords

ASJC Scopus subject areas

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