Recent insight into autophagy and immunity at the maternal-fetal interface

Yuanyao Chen, Lin Xiao, Jia Xu, Jingming Wang, Zhiquan Yu, Kai Zhao, Huiping Zhang, Shibin Cheng, Surendra Sharma, Aihua Liao, Chunyan Liu

Research output: Contribution to journalReview articlepeer-review


Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects.

Original languageEnglish (US)
Article number103781
JournalJournal of Reproductive Immunology
StatePublished - Feb 2023
Externally publishedYes


  • Autophagy
  • adaptive immunity
  • immune tolerance molecules
  • innate immunity
  • maternal-fetal interface

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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