TY - JOUR
T1 - Recent advances and prospects of hyaluronan as a multifunctional therapeutic system
AU - Kotla, Niranjan G.
AU - Bonam, Srinivasa Reddy
AU - Rasala, Swetha
AU - Wankar, Jitendra
AU - Bohara, Raghvendra A.
AU - Bayry, Jagadeesh
AU - Rochev, Yury
AU - Pandit, Abhay
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/8/10
Y1 - 2021/8/10
N2 - Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-surface-associated biopolymer and is the key component of tissue extracellular matrix (ECM). Along with remarkable physicochemical properties, HA also has multifaceted biological effects that include but not limited to ECM organization, immunomodulation, and various cellular processes. Environmental cues such as tissue injury, infection or cancer change downstream signaling functionalities of HA. Unlike native HA, the fragments of HA have diversified effects on inflammation, cancer, fibrosis, angiogenesis and autoimmune response. In this review, we aim to discuss HA as a therapeutic delivery system development process, source, biophysical-chemical properties, and associated biological pathways (especially via cell surface receptors) of native and fragmented HA. We also tried to address an overview of the potential role of HA (native HA vs fragments) in the modulation of inflammation, immune response and various cancer targeting delivery applications. This review will also highlight the HA based therapeutic systems, medical devices and future perspectives of various biomedical applications were discussed in detail.
AB - Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-surface-associated biopolymer and is the key component of tissue extracellular matrix (ECM). Along with remarkable physicochemical properties, HA also has multifaceted biological effects that include but not limited to ECM organization, immunomodulation, and various cellular processes. Environmental cues such as tissue injury, infection or cancer change downstream signaling functionalities of HA. Unlike native HA, the fragments of HA have diversified effects on inflammation, cancer, fibrosis, angiogenesis and autoimmune response. In this review, we aim to discuss HA as a therapeutic delivery system development process, source, biophysical-chemical properties, and associated biological pathways (especially via cell surface receptors) of native and fragmented HA. We also tried to address an overview of the potential role of HA (native HA vs fragments) in the modulation of inflammation, immune response and various cancer targeting delivery applications. This review will also highlight the HA based therapeutic systems, medical devices and future perspectives of various biomedical applications were discussed in detail.
KW - Cancer
KW - Drug delivery
KW - Hyaluronic acid
KW - Immunity
KW - Inflammation
KW - Low and high molecular weight HA
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U2 - 10.1016/j.jconrel.2021.07.002
DO - 10.1016/j.jconrel.2021.07.002
M3 - Review article
C2 - 34237401
AN - SCOPUS:85109541814
SN - 0168-3659
VL - 336
SP - 598
EP - 620
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -