Purpura fulminans and late onset group B streptococcal sepsis in a premature twin

Avanikkha Elayappen, Sunil K. Jain, Michael J. Loeffelholz, Janak Patel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Introduction: Purpura fulminans (PF) is a skin manifestation due to hemorrhagic infarction caused by intravascular thrombosis secondary to bacterial infections or deficiency of anticoagulants such as protein C and protein S. Neonatal PF is a rare but potentially disabling disorder associated with a high mortality and severe long term morbidity in those who survive. Case description: We report a case of a premature infant who developed extensive PF due to late onset group B streptococcus sepsis. Despite early identification and initiation of antibiotic therapy in our patient, PF progressed rapidly, leading to autoamputation of fingers and toes and severe brain injury. Conclusion: In conclusion, our case highlights the severe sequelae of PF due to late onset GBS sepsis in a premature infant.

Original languageEnglish (US)
Pages (from-to)e69-e72
JournalAJP Reports
Issue number2
StatePublished - May 12 2014


  • GBS
  • coagulation
  • meningitis
  • neonate
  • purpura fulminans
  • serotype Ia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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