@article{50ef64e3768f4f6198ac81af77296d46,
title = "Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain",
abstract = "Chelation of excessive neuronal zinc ameliorates zinc neurotoxicity and reduces subsequent neuronal injury. To clarify the molecular mechanisms of this neuroprotective effect, we used a focused cDNA array of stress-response genes with zinc chelation (calcium EDTA) in our rat model of fluid percussion brain injury at 2 h, 24 h, and 7 days after injury. In parallel experiments, we compared neuronal cell death in TUNEL-stained brain sections in traumatized rats with and without calcium EDTA treatment. Zinc chelation induced the expression of several neuroprotective genes; neuroprotective gene expression correlated with substantially decreased numbers of TUNEL-positive cells.",
keywords = "Apoptosis, Gene expression, Neuroprotection, Traumatic brain injury, Zinc",
author = "Helen Hellmich and Frederickson, {Christopher J.} and DeWitt, {Douglas S.} and Ricardo Saban and Parsley, {Margaret O.} and Rachael Stephenson and Marco Velasco and Tatsuo Uchida and Megumi Shimamura and Prough, {Donald S.}",
note = "Funding Information: This study was funded by a grant from the University of Texas Medical Branch John Sealy Memorial Endowment Fund for Biomedical Research #2558-01 (to H.L.H.) and NIH grant NS19355 (to D.S.D.), and supported in part by NIH grants NS40215, NS38585, and NS42882 (to C.J.F.). We thank Dr Marcia Saban and Becky Nguyen for their valuable assistance with the microarray data analysis, Dr Cheng Lin for his help with the RPAs, Christy Perry for her assistance in scanning and analyzing the microarray data and for preparing figures for the manuscript, and Jordan Kicklighter and Lauren Tunnell for editing and preparing the manuscript.",
year = "2004",
month = jan,
day = "30",
doi = "10.1016/j.neulet.2003.10.074",
language = "English (US)",
volume = "355",
pages = "221--225",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}