TY - JOUR
T1 - Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria
AU - Gutiérrez-Pérez, Areli
AU - Cortés-Rojo, Christian
AU - Noriega-Cisneros, Ruth
AU - Calderón-Cortés, Elizabeth
AU - Manzo-Avalos, Salvador
AU - Clemente-Guerrero, Mónica
AU - Godínez-Hernández, Daniel
AU - Boldogh, Istvan
AU - Saavedra-Molina, Alfredo
N1 - Funding Information:
Acknowledgments The authors appreciate the financial support from CIC-UMSNH 2.16 (ASM); CONACYT (144250 to ASM during his sabbatical). CONACYT 130638 (CCR); PROMEP PTC-266 (CCR). We greatly appreciate editorial revision of Mardelle Susman (Dept. of Microbiology and Immunology, UTMB).
PY - 2011/4
Y1 - 2011/4
N2 - Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe2+ + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.
AB - Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe2+ + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.
KW - Calcium-overload
KW - Cardioprotection
KW - Mitochondria
KW - Oxidative stress
KW - Resveratrol
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U2 - 10.1007/s10863-011-9349-4
DO - 10.1007/s10863-011-9349-4
M3 - Article
C2 - 21448653
AN - SCOPUS:79958256678
SN - 0145-479X
VL - 43
SP - 101
EP - 107
JO - Journal of Bioenergetics and Biomembranes
JF - Journal of Bioenergetics and Biomembranes
IS - 2
ER -