Prospects for a virus non-structural protein as a subunit vaccine

Carl A. Gibson; Jacob J. Schlesinger; Alan D.T. Barrett

doi:10.1016/0264-410X(88)90004-7

Prospects for a virus non-structural protein as a subunit vaccine

Carl A. Gibson, Jacob J. Schlesinger, Alan D.T. Barrett

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

Original language	English (US)
Pages (from-to)	7-9
Number of pages	3
Journal	Vaccine
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0264-410X(88)90004-7
State	Published - Feb 1988
Externally published	Yes

Keywords

Flavivirus
immunity
non-structural protein

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/0264-410X(88)90004-7

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abstract = "The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.",

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AU - Schlesinger, Jacob J.

AU - Barrett, Alan D.T.

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N2 - The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

AB - The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

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KW - immunity

KW - non-structural protein

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Prospects for a virus non-structural protein as a subunit vaccine

Abstract

Keywords

ASJC Scopus subject areas

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