Prospects for a virus non-structural protein as a subunit vaccine

Carl A. Gibson, Jacob J. Schlesinger, Alan D.T. Barrett

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

Original languageEnglish (US)
Pages (from-to)7-9
Number of pages3
Issue number1
StatePublished - Feb 1988
Externally publishedYes


  • Flavivirus
  • immunity
  • non-structural protein

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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