Proliferative glomerulonephritis with monoclonal IgG deposits: a unique case with a clinical course of over 46 years

Tyler James, Marjan Afrouzian, Luan Truong, Omar Aleter, John Badalamenti, Hania Kassem

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a rare entity first described in 2004. We present a case of PGNMID with recurrent hematuria and nephrotic range proteinuria with three biopsies over 46 years. Case presentation: A 79-year-old Caucasian female presents with a history of two separate episodes of biopsy-proven recurrent GN over a course of 46 years. Both biopsies from 1974, and 1987 were reported as membranoproliferative GN (MPGN). The patient presented in 2016 for the third time with symptoms of fluid overload, slight worsening in renal function, and proteinuria along with glomerular hematuria. A third kidney biopsy was performed, and the final diagnosis was proliferative glomerulonephritis with monoclonal IgG/κ deposits. Conclusion: With three renal biopsies obtained over 46 years, our case opens a unique window into the natural history of PGNMID. The three biopsies demonstrate the immunologic and morphologic evolution of PGNMID in the kidney.

Original languageEnglish (US)
Article number109
JournalBMC Nephrology
Volume24
Issue number1
DOIs
StatePublished - Dec 2023
Externally publishedYes

Keywords

  • Case report
  • IgG
  • Monoclonal deposits
  • Proliferative glomerulonephritis
  • Prolonged follow-up

ASJC Scopus subject areas

  • Nephrology

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