Primary aldosteronism

O. B. Holland

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Primary aldosteronism occurs much more commonly than generally appreciated. Diagnosis is facilitated by measuring urinary aldosterone excretion in conjunction with determination of the level of plasma aldosterone suppression after infusion of 2,000 mL of normal saline over 4 hours. Multiple diagnostic procedures are required to determine the specific type of primary aldosteronism. Patients with aldosterone-producing tumors, unilateral adrenal hyperplasia, and primary adrenal hyperplasia are treated surgically, whereas those with bilateral zona glomerulosa hyperplasia and glucocorticoid-remediable aldosteronism are treated medically.

Original languageEnglish (US)
Pages (from-to)116-125
Number of pages10
JournalSeminars in nephrology
Issue number2
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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