Prevalence of resistant hypertension and eligibility for catheter-based renal denervation in hypertensive outpatients

Salim S. Hayek, Mahmoud H. Abdou, Benjamin D. Demoss, Juan M.Ortega Legaspi, Emir Veledar, Anjan Deka, Sandeep K. Krishnan, Kobina A. Wilmot, Aalok D. Patel, Vikas R. Kumar, Chandan M. Devireddy

Research output: Contribution to journalArticlepeer-review

Abstract

Background Studies of endovascular renal denervation (RDN) have demonstrated significant blood pressure reduction in eligible patients with resistant hypertension. These trials have used stringent inclusion and exclusion criteria in patient enrollment, potentially selecting for a small subset of patients with resistant hypertension. In this study, we examined the changes in estimated prevalence of resistant hypertension when using increasingly stringent definitions of resistant hypertension in a fixed population and assessed the generalizability of RDN when applying study criteria to a community-based hypertensive population. methods A retrospective chart review was done of hypertensive outpatients. Four increasingly stringent interpretations of the American Heart Association definition of resistant hypertension were used to calculate prevalence estimates. Patients eligible for RDN were identified using criteria from SYMPLICITY HTN-3. Demographic and clinical characteristics were compared. results We identified 1,756 hypertensive outpatients; 55.0% were male, 53.9% were white, and subjects had a mean age of 66.6 ± 12.5 years and a body mass index (BMI) of 30.1 ± 10.7 kg/m2. Only 14 (0.8%) were eligible for RDN. Among these patients, 10 (71.4%) were female and all were black, with a mean age of 69.9 ± 8.8 and BMI of 35.7 ± 6.6. Congestive heart failure was more common in patients eligible for RDN. conclusions Patients eligible for RDN based on published studies represent an exceedingly small proportion of the total hypertensive population. Further studies are necessary to determine if the benefits of RDN can be generalized to a broader range of hypertensive patients than those included in previous trials.

Original languageEnglish (US)
Pages (from-to)1452-1458
Number of pages7
JournalAmerican journal of hypertension
Volume26
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Blood pressure
  • Hypertension
  • Prevalence
  • Renal denervation
  • Resistant hypertension
  • SYMPLICITY HTN

ASJC Scopus subject areas

  • Internal Medicine

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