Abstract
The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.
Original language | English (US) |
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Article number | 8626 |
Journal | Scientific reports |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1 2020 |
ASJC Scopus subject areas
- General