Predisposing Factors for 30-Day Complications Following Leg Amputation

Joseph V. Villarreal, Doha G. Hussien, Vinod K. Panchbhavi, Daniel C. Jupiter

Research output: Contribution to journalArticlepeer-review


Background: Although amputation rates, morbidity, and mortality have been established for select populations, the impact of general demographic factors on postoperative surgical complications remains little studied. Methods: The American College of Surgeons’ National Surgical Quality Improvement Program database was searched for leg amputations from 2012 to 2017 using CPT codes 27881, 27882, 27884, and 27886, identifying 4162 patients. A total of 29 demographic variables with 4 complications (surgical infection, additional service, and deep-vein thrombosis [DVT], and sepsis) were analyzed. Results: Preoperative open, contaminated, or dirty/infected wounds; longer intraoperative times; development of sepsis prior to surgery; and admission of patients from home or another hospital influenced postoperative infection rates. Preoperative open, infected, or dirty/infected wounds; height; weight; total length of hospital stay; and ethnicity affected postoperative additional service incidence. Preoperative congestive heart failure, large decreases in body weight, and total length of hospital stay influenced postoperative DVT rates. Preoperative functional heath status, total length of hospital stay, amputations conducted as emergency cases, preoperative acute renal failure, open or infected wounds, sepsis, and contaminated or dirty/infected wounds affected postoperative sepsis rates. Background: Conclusion. Understanding these risk factors may allow providers to anticipate and address higher rates of complications in certain patient populations.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalFoot and Ankle Specialist
Issue number1
StatePublished - Feb 2024


  • lower extremity amputation
  • patient risk factors
  • postoperative complications
  • surgical outcomes

ASJC Scopus subject areas

  • Surgery
  • Podiatry
  • Orthopedics and Sports Medicine


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